Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds
| Autor: | Mengxing Lu, Guangqian Lan, Kun Yu, Enling Hu, Ruiqi Xie, Qing Li, Fei Lu, Rong Bao, Bitao Lu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Severe bleeding
Materials science QH301-705.5 0206 medical engineering Biomedical Engineering Janus particles 02 engineering and technology Femoral artery Article Biomaterials medicine.artery Complex wound medicine Biology (General) Materials of engineering and construction. Mechanics of materials Hemostasis Hemostatic drug Surgical procedures Magnetic guidance 021001 nanoscience & nanotechnology Janus particle 020601 biomedical engineering Sustained driving TA401-492 0210 nano-technology Drug carrier human activities Tranexamic acid Biotechnology Biomedical engineering medicine.drug |
| Zdroj: | Bioactive Materials Bioactive Materials, Vol 6, Iss 12, Pp 4625-4639 (2021) |
| ISSN: | 2452-199X |
| Popis: | Severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex challenge. Therefore, we present a novel hemostatic strategy based on magnetic field-mediated guidance. The biphasic Janus magnetic particle (MSS@Fe2O3-T) comprised aggregates of α-Fe2O3 nanoparticles (Fe2O3 NPs) as the motion actuator, negatively modified microporous starch (MSS) as the base hemostatic substrate, and thrombin as the loaded hemostatic drug. Before application, the particles were first wrapped using NaHCO3 and then doped with protonated tranexamic acid (TXA-NH3+), which ensured their high self-dispersibility in liquids. During application, the particles promptly self-diffused in blood by bubble propulsion and travelled to deep bleeding sites against reverse rushing blood flow under magnetic guidance. In vivo tests confirmed the superior hemostatic performance of the particles in perforating and inflected wounds (“V”-shaped femoral artery and “J”-shaped liver bleeding models). The present strategy, for the first time, extends the range of magnetically guided drug carriers to address the challenges in the hemorrhage control of perforating and inflected wounds. Graphical abstract Image 1 Highlights • A new Janus hemostat was developed for treating severe bleeding. • The “J” shape bleeding model was proposed for hemostatic test. • Magnetic field-mediated driving capacity was employed for hemostasis. • Explosive self-dispersibility endowed to the hemostat largely enhanced the bleeding control capacity. |
| Databáze: | OpenAIRE |
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