Structure-function relationship in glaucoma: Optical coherence tomography en face imaging vs. red-free fundus photography

Autor: Eunoo Bak, Hyuk Jin Choi
Rok vydání: 2023
Předmět:
Zdroj: Eye.
ISSN: 1476-5454
0950-222X
DOI: 10.1038/s41433-023-02452-9
Popis: Background/Objectives: To analyze retinal nerve fiber layer (RNFL) defect measurements obtained from red-free fundus photography and optical coherence tomography (OCT) en face imaging, respectively, and to compare them for the strength of the structure–function association. Subjects/Methods: Two hundred and fifty-six glaucomatous eyes with localized RNFL defect on red-free fundus photography were enrolled. A subgroup analysis included 81 highly myopic eyes (≤–6.0 diopters). Angular width of RNFL defect was compared between red-free fundus photography (i.e., red-free RNFL defect) and OCT en face imaging (i.e., en face RNFL defect). The correlation between angular width of each RNFL defect and functional outcomes, reported as mean deviation (MD) and pattern standard deviation (PSD), were assessed and compared. Results: The angular width of en face RNFL defect was measured smaller than that of red-free RNFL defect in 91.0% eyes (mean difference, 19.98°). The association of en face RNFL defect with MD and PSD was stronger (R2=0.311 and R2=0.372, respectively) than that of red-free RNFL defect with MD and PSD (R2=0.162 and R2=0.137, respectively) (P < 0.05 for all). Especially in highly myopic eyes, the association of en face RNFL defect with MD and PSD was much stronger (R2=0.503 and R2=0.555, respectively) than that of red-free RNFL defect with MD and PSD (R2=0.216 and R2=0.166, respectively) (P < 0.05 for all). Conclusions: En face RNFL defect showed a higher correlation with severity of visual field loss than did red-free RNFL defect. The same dynamic was observed for highly myopic eyes.
Databáze: OpenAIRE
Externí odkaz: