Rotational field TMS: Comparison with conventional TMS based on motor evoked potentials and thresholds in the hand and leg motor cortices
| Autor: | Abraham Zangen, Elisha Moses, Yafit Hadad, Moria Ankry, Yiftach Roth, Noam Barnea-Ygael, Ami Eisen, Aron Tendler, Yuri Burnishev, Gaby S. Pell |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_treatment Population Biophysics Stimulation 050105 experimental psychology lcsh:RC321-571 Motor threshold 03 medical and health sciences 0302 clinical medicine Rotational field Electric field Neuroplasticity medicine Humans 0501 psychology and cognitive sciences Evoked potential education lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Physics Leg education.field_of_study Electromyography General Neuroscience 05 social sciences MEP Evoked Potentials Motor Hand Transcranial Magnetic Stimulation Transcranial magnetic stimulation medicine.anatomical_structure Electromagnetic coil TMS Unidirectional Motor cortex Female Neurology (clinical) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Stimulation, Vol 13, Iss 3, Pp 900-907 (2020) |
| ISSN: | 1935-861X |
| DOI: | 10.1016/j.brs.2020.03.010 |
| Popis: | Background Transcranial magnetic stimulation (TMS) is a rapidly expanding technology utilized in research and neuropsychiatric treatments. Yet, conventional TMS configurations affect primarily neurons that are aligned parallel to the induced electric field by a fixed coil, making the activation orientation-specific. A novel method termed rotational field TMS (rfTMS), where two orthogonal coils are operated with a 90° phase shift, produces rotation of the electric field vector over almost a complete cycle, and may stimulate larger portion of the neuronal population within a given brain area. Objective To compare the physiological effects of rfTMS and conventional unidirectional TMS (udTMS) in the motor cortex. Methods Hand and leg resting motor thresholds (rMT), and motor evoked potential (MEP) amplitudes and latencies (at 120% of rMT), were measured using a dual-coil array based on the H7-coil, in 8 healthy volunteers following stimulation at different orientations of either udTMS or rfTMS. Results For both target areas rfTMS produced significantly lower rMTs and much higher MEPs than those induced by udTMS, for comparable induced electric field amplitude. Both hand and leg rMTs were orientation-dependent. Conclusions rfTMS induces stronger physiologic effects in targeted brain regions at significantly lower intensities. Importantly, given the activation of a much larger population of neurons within a certain brain area, repeated application of rfTMS may induce different neuroplastic effects in neural networks, opening novel research and clinical opportunities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect