Operculina macrocarpa: chemical and intestinal motility effect in mice
| Autor: | Miriam Sannomiya, Hérida Regina Nunes Salgado, Daniel Rinaldo, Daniele Michelin Paganotte, Wagner Vilegas |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP), Ctr Univ Herminio Ometto |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_treatment
Phenolic acids Population Operculina Macrocarapa Laxative lcsh:RS1-441 01 natural sciences lcsh:Pharmacy and materia medica chemistry.chemical_compound Pharmacology Toxicology and Pharmaceutics(all) Caffeic acid medicine HPLC-UV-PDA General Pharmacology Toxicology and Pharmaceutics education education.field_of_study Traditional medicine biology 010405 organic chemistry Experimental model Operculina macrocarpa food and beverages Batata-de-purga FITOTERAPIA biology.organism_classification 0104 chemical sciences Intestinal motility 010404 medicinal & biomolecular chemistry Biochemistry chemistry Intestinal transit Batata-depurga Convolvulaceae |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 26, Iss 4, Pp 427-432 Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Revista Brasileira de Farmacognosia, Vol 26, Iss 4, Pp 427-432 (2016) Revista Brasileira de Farmacognosia, Volume: 26, Issue: 4, Pages: 427-432, Published: AUG 2016 Revista Brasileira de Farmacognosia v.26 n.4 2016 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| ISSN: | 0102-695X |
| DOI: | 10.1016/j.bjp.2016.03.003 |
| Popis: | Made available in DSpace on 2018-11-26T17:06:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-07-01. Added 1 bitstream(s) on 2021-07-15T14:31:54Z : No. of bitstreams: 1 S0102-695X2016000400427.pdf: 541368 bytes, checksum: 506a3f3bed1b2d0690bc1ecc14a4ca73 (MD5) Operculina macrocarpa (L.) Urb., Convolvulaceae, is used by the population as a laxative. In this work we described the isolation of the three phenolic acids present in the hydroethanolic extract of the O. macrocarpa roots. The quantification of the caffeic, chlorogenic acids and of the new caffeic dimer in the hydroethanolic and infusion extracts was performed by high-performance liquid chromatography coupled photodiode array detector. These analyses showed the higher content of the chlorogenic, caffeic and the new 3,4'-dehydrodicaffeic acid in hydroethanolic and hydroethanolic extracts without resin in which infusion. The acid found in greater quantity is caffeic acid followed by the 3,4'-dehydrodicaffeic acid. The laxative activity was evaluated by different experimental models of intestinal transit with the hydroethanolic and infusion extracts, and the resin fraction, caffeic, chlorogenic and ferulic acids. The results showed all extracts and compounds tested had significant activity in the experimental model tested. These results obtained are essential for the future development of a pharmaceutical product with safety and efficacy. (C) 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Med, Programa Posgrad Ciencias Farmaceut, Araraquara, SP, Brazil Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo, SP, Brazil Univ Estadual Paulista, Fac Ciencias, Dept Quim, Bauru, SP, Brazil Univ Estadual Paulista, Campus Litorai Paulista, Sao Vicente, SP, Brazil Ctr Univ Herminio Ometto, Fundacao Heiminio Ometto, Araras, SP, Brazil Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Med, Programa Posgrad Ciencias Farmaceut, Araraquara, SP, Brazil Univ Estadual Paulista, Fac Ciencias, Dept Quim, Bauru, SP, Brazil Univ Estadual Paulista, Campus Litorai Paulista, Sao Vicente, SP, Brazil |
| Databáze: | OpenAIRE |
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