Thrombin-induced vascular reactivity is modulated by ETB receptor-coupled nitric oxide release in rat aorta
| Autor: | K. D. Srivastava, H. I. Magazine |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Contraction (grammar) Physiology Vasodilation Biology Nitric Oxide Nitric oxide Rats Sprague-Dawley chemistry.chemical_compound Thrombin Internal medicine medicine Animals Receptor Aorta Receptors Endothelin Cell Biology Endothelin 1 Rats Endocrinology chemistry cardiovascular system Signal transduction Endothelin receptor circulatory and respiratory physiology medicine.drug Muscle Contraction Signal Transduction |
| Zdroj: | The American journal of physiology. 271(3 Pt 1) |
| ISSN: | 0002-9513 |
| Popis: | The role of endothelin (ET) receptors in thrombin-induced modulation of vascular tone was evaluated by direct measurement of ET-1 and ET receptor-coupled nitric oxide (NO) release and developed isometric tension in thrombin-treated aortic rings. Here we report that rapid release of ET-1 and subsequent ETB receptor activation are required for production of the potent vasodilator NO by thrombin-stimulated aorta. Thrombin-induced NO release is ablated by pretreatment with ETB receptor antagonists or after ET receptor desensitization by repeated stimulation with ET-1. Thrombin-induced relaxation of precontracted vessels was abrogated in the presence of ETB receptor antagonists and, in contrast, marked contraction to thrombin was observed. These data indicate that the endothelium-dependent vasodilator activity previously attributed to thrombin is indirect and requires ETB receptor-coupled NO release and suggest that ET receptor modulation of thrombin-induced vascular tone may contribute to the increased vasomotor tone observed in diseased and mechanically injured vessels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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