Physiological costs of infection : herpesvirus replication is linked to blood oxidative stress in equids
| Autor: | Alex D. Greenwood, Jörg Melzheimer, Marie Simon, Nikolaus Osterrieder, Sanatana-Eirini Soilemetzidou, Petra Kaczensky, Walid Azab, Kenneth Uiseb, Ditte-Mari Sandgreen, Eva Maria Greunz, Chris Walzer, David Costantini, Julia Bohner, Marion L. East, Bayarbaatar Buuveibaatar, Benjamin Lamglait, Peter A. Seeber, Gábor Á. Czirják, Alix Ortega |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Pathogens Ecophysiology Equus ferus caballus Zoology and botany: 480 [VDP] Zoology lcsh:Medicine medicine.disease_cause Virus Replication Article Protein Carbonylation 03 medical and health sciences chemistry.chemical_compound herpesvirus Species Specificity biology.animal medicine media_common.cataloged_instance Plains zebra Animals Horses Least-Squares Analysis lcsh:Science Zoologiske og botaniske fag: 480 [VDP] Herpesviridae media_common chemistry.chemical_classification Glutathione Peroxidase Multidisciplinary biology Glutathione peroxidase lcsh:R Glutathione Equidae Herpesviridae Infections biology.organism_classification Equus Oxidative Stress 030104 developmental biology chemistry Viral replication DNA Viral Female lcsh:Q Engineering sciences. Technology Oxidative stress |
| Zdroj: | Scientific reports Scientific Reports Scientific reports, 8:10347 Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Viruses may have a dramatic impact on the health of their animal hosts. The patho-physiological mechanisms underlying viral infections in animals are, however, not well understood. It is increasingly recognized that oxidative stress may be a major physiological cost of viral infections. Here we compare three blood-based markers of oxidative status in herpes positive and negative individuals of the domestic horse (Equus ferus caballus) and of both captive and free-ranging Mongolian khulan (Equus hemionus hemionus) and plains zebra (Equus quagga). Herpes positive free-ranging animals had significantly more protein oxidative damage and lower glutathione peroxidase (antioxidant enzyme) than negative ones, providing correlative support for a link between oxidative stress and herpesvirus infection in free-living equids. Conversely, we found weak evidence for oxidative stress in herpes positive captive animals. Hence our work indicates that environment (captive versus free living) might affect the physiological response of equids to herpesvirus infection. The Mongolian khulan and the plains zebra are currently classified as near threatened by the International Union for Conservation of Nature. Thus, understanding health impacts of pathogens on these species is critical to maintaining viable captive and wild populations. |
| Databáze: | OpenAIRE |
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