Spermatogonial Stem Cell Culture in Oncofertility
| Autor: | Sherin David, Kyle E. Orwig |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Infertility
Male endocrine system Urology media_common.quotation_subject 030232 urology & nephrology Fertility Cryopreservation Article Andrology 03 medical and health sciences 0302 clinical medicine Neoplasms Medicine Humans Fertility preservation Spermatogenesis Infertility Male Oncofertility media_common Adult Germline Stem Cells business.industry Fertility Preservation medicine.disease Sperm Transplantation 030220 oncology & carcinogenesis business Stem Cell Transplantation |
| Zdroj: | Urol Clin North Am |
| ISSN: | 1558-318X |
| Popis: | Infertility caused by chemotherapy or radiation treatments negatively impacts patient-survivor quality of life. The only fertility preservation option available to prepubertal boys who are not making sperm is cryopreservation of testicular tissues that contain spermatogonial stem cells (SSCs) with potential to produce sperm and/or restore fertility. SSC transplantation to regenerate spermatogenesis in infertile adult survivors of childhood cancers is a mature technology. However, the number of SSCs obtained in a biopsy of a prepubertal testis may be small. Therefore, methods to expand SSC numbers in culture before transplantation are needed. Here we review progress with human SSC culture. |
| Databáze: | OpenAIRE |
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