Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation
| Autor: | Chao Shun Chan, Yen Yu Lu, Yi Jen Chen, Shih Ann Chen, Yao Chang Chen, Yung Kuo Lin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
sinoatrial node sinoatrial node dysfunction pulmonary veins heart failure Review 030204 cardiovascular system & hematology Atrial stretch Catalysis Sick sinus syndrome Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Adrenergic stimulation Fibrosis Internal medicine medicine Animals Humans atrial fibrillation 030212 general & internal medicine Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Sinoatrial node business.industry Organic Chemistry Atrial fibrillation General Medicine medicine.disease Computer Science Applications Electrophysiology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Heart failure Cardiology cardiovascular system business Anti-Arrhythmia Agents |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 13, p 3224 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atrial stretch, and fibrosis. Pulmonary veins (PVs), which are the points of onset of ectopic electrical activity, are the most crucial AF triggers. A crosstalk between the SAN and PVs determines PV arrhythmogenesis. HF has different effects on SAN and PV electrophysiological characteristics, which critically modulate the development of AF and sick sinus syndrome. This review provides updates to improve our current understanding of the effects of HF in the electrical activity of the SAN and PVs as well as therapeutic implications for AF. |
| Databáze: | OpenAIRE |
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