Multistress Regulation in Escherichia coli : Expression of osmB Involves Two Independent Promoters Responding either to σ S or to the RcsCDB His-Asp Phosphorelay
| Autor: | Anne Francez-Charlot, Annie Conter, Claude Gutierrez, Alice Boulanger, Marie-Pierre Castanié-Cornet, Kaymeuang Cam |
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| Rok vydání: | 2005 |
| Předmět: |
DNA
Bacterial Lipoproteins Molecular Sequence Data Protein Data Bank (RCSB PDB) Sigma Factor Biology Microbiology Bacterial Proteins Transcription (biology) Sigma factor Escherichia coli Gene Regulation Histidine Promoter Regions Genetic Molecular Biology Transcription factor Gene Regulation of gene expression Genetics Aspartic Acid Base Sequence Escherichia coli Proteins Promoter Gene Expression Regulation Bacterial Adaptation Physiological Response regulator Periplasmic Proteins Bacterial Outer Membrane Proteins Signal Transduction Transcription Factors |
| Zdroj: | Journal of Bacteriology. 187:3282-3286 |
| ISSN: | 1098-5530 0021-9193 |
| Popis: | Transcription of the Escherichia coli osmB gene is induced by several stress conditions. osmB is expressed from two promoters, osmBp1 and osmBp2 . The downstream promoter, osmBp2 , is induced after osmotic shock or upon entry into stationary phase in a σ S -dependent manner. The upstream promoter, osmBp1 , is independent of σ S and is activated by RcsB, the response regulator of the His-Asp phosphorelay signal transduction system RcsCDB. RcsB is responsible for the induction of osmBp1 following treatment with chlorpromazine. Activation of osmBp1 by RcsB requires a sequence upstream of its −35 element similar to the RcsB binding site consensus, suggesting a direct regulatory role. osmB appears as another example of a multistress-responsive gene whose transcription involves both a σ S -dependent promoter and a second one independent of σ S but controlled by stress-specific transcription factors. |
| Databáze: | OpenAIRE |
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