Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency
| Autor: | F.G. Njoroge, Anil K. Saksena, Vincent Madison, V. Girijavallabhan, Haining Gu, John Pichardo, Ashok Arasappan, Nancy Butkiewicz, Andrew Prongay, Stephane L. Bogen |
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| Rok vydání: | 2005 |
| Předmět: |
Serine Proteinase Inhibitors
Hepatitis C virus Hepacivirus Clinical Biochemistry Pharmaceutical Science Viral Nonstructural Proteins medicine.disease_cause Biochemistry Virus X-Ray Diffraction Drug Discovery medicine Potency Protease inhibitor (pharmacology) Molecular Biology chemistry.chemical_classification Alanine biology Organic Chemistry virus diseases biology.organism_classification digestive system diseases Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine |
| Zdroj: | Bioorganicmedicinal chemistry letters. 15(20) |
| ISSN: | 0960-894X |
| Popis: | Modification of the P2 and P1 side chains of earlier P3-capped α-ketoamide inhibitor of HCV NS3 serine protease 1 resulted in the discovery of compound 24 with about 10-fold improvement in potency. |
| Databáze: | OpenAIRE |
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