Concomitant variations of gastric tone and duodenal motility in humans: Results of a placebo-controlled study assessing octreotide and sumatriptan
| Autor: | Guillaume Savoye, Philippe Denis, Grégory Mosni, Mickael Bouin, Philippe Ducrotté, Louis Labbé, Paola Morcamp |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Duodenum Octreotide Placebo Placebos Gastrointestinal Agents medicine Humans Sumatriptan business.industry Stomach Gastroenterology Middle Aged musculoskeletal system Barostat medicine.anatomical_structure Somatostatin Concomitant Anesthesia cardiovascular system Gastrointestinal Motility business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 41:536-543 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | To describe the concomitant effects of octreotide and sumatriptan on fundic tone and duodenal phase III activity.A double-blind study was performed in nine volunteers, studied for 2 h after receiving 50 microg octreotide, 6 mg sumatriptan or placebo. Fundic tone variations were assessed by barostat while antroduodenal motility was studied concomitantly using manometry.A rapid increase in intrabag volume was observed in all but one subject after both sumatriptan and octreotide administration, while only two subjects exhibited a volume variation after placebo, p0.01. A significant decrease in the number of phasic contractions was observed after octreotide, while sumatriptan reduced only wave amplitudes (p0.05). A total of 13 concomitant duodenal phase III-like activities were observed in the duodenum after octreotide, 3 after sumatriptan and 4 after placebo, all followed by spontaneous fundic relaxation with disappearance of phasic contractions, p0.05. Spontaneous phase III activities were different from phases III-like activities after octreotide in velocity and duration (p0.05).Octreotide induced concomitant fundic relaxation, disappearance of phasic contractions and duodenal phase III-like activity. Sumatriptan relaxed the proximal stomach and reduced the amplitude of fundic phasic contractions without affecting concomitant antroduodenal phase III activity. |
| Databáze: | OpenAIRE |
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