Dietary n-3 polyunsaturated fatty acids or soy protein isolate did not attenuate disease progression in a female rat model of autosomal recessive polycystic kidney disease
| Autor: | Janet C. Tou, Ryan H. Livengood, Vagner A. Benedito, Nainika Nanda, Kaitlin H Maditz, Chris Oldaker |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Diet therapy Endocrinology Diabetes and Metabolism Autosomal dominant polycystic kidney disease Biology Kidney Blood Urea Nitrogen Endocrinology Internal medicine Fatty Acids Omega-3 Polycystic kidney disease medicine Animals Cyst Soy protein Polycystic Kidney Autosomal Recessive chemistry.chemical_classification Nutrition and Dietetics Body Weight Fatty Acids medicine.disease Eicosapentaenoic acid Autosomal Recessive Polycystic Kidney Disease Rats Soybean Oil chemistry Disease Progression Soybean Proteins Female Biomarkers Polyunsaturated fatty acid |
| Zdroj: | Nutrition research (New York, N.Y.). 34(6) |
| ISSN: | 1879-0739 |
| Popis: | Polycystic kidney disease (PKD) is an incurable genetic disorder that is characterized by multiple benign cysts. As PKD advances, cyst growth increases kidney volume, decreases renal function, and may lead to end-stage renal disease; however, in a PKD rat model, feeding soy protein isolate (SPI) reduced cyst proliferation and growth. The n-3 polyunsaturated fatty acids (PUFAs) are noted for their anti-inflammatory actions. Therefore, diet therapy could offer a potentially efficacious, safe, and cost-effective strategy for treating PKD. The objective of this study was to investigate the role of soy protein and/or n-3 PUFAs on PKD progression and severity in the rat model of autosomal recessive PKD. We hypothesized that the antiproliferative and anti-inflammatory actions associated with soy protein and n-3 PUFA supplementation will attenuate PKD progression in female PCK rats. For 12 weeks, young (age, 28 days) female PCK rats were randomly assigned (n=12/group) to 4 different diets: casein±corn oil, casein±soybean oil, SPI±soybean oil, or SPI±1:1 soybean/salmon oil (SPI±SB). The feeding of the different protein and lipid sources had no significant effect on relative kidney weight. Histologic evaluation showed no significant differences in cortical or medullary cyst size, interstitial inflammation, and fibrosis among diet groups. However, rats fed SPI±SB diet had cortical cyst obstruction and the highest (P |
| Databáze: | OpenAIRE |
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