Mechanisms of complement lectin pathway activation and resistance by trypanosomatid parasites
| Autor: | Luregn J. Schlapbach, Iara de Messias-Reason, Igor Cestari, Ingrid Evans-Osses, Marcel I. Ramirez |
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| Rok vydání: | 2012 |
| Předmět: |
Trypanosoma
Immunology Gene Expression Complement receptor Biology Mannose-Binding Lectin Host-Parasite Interactions Classical complement pathway Immune system Lectins Animals Humans Chagas Disease Molecular Biology Mannan-binding lectin Immune Evasion Innate immune system Complement Pathway Mannose-Binding Lectin Complement System Proteins Immunity Innate Complement system Trypanosomiasis African Lectin pathway Alternative complement pathway Variant Surface Glycoproteins Trypanosoma |
| Zdroj: | Molecular immunology. 53(4) |
| ISSN: | 1872-9142 |
| Popis: | Studies in the past decade have demonstrated a crucial role for the complement lectin pathway in host defence against protozoan microbes. Recognition of pathogen surface molecules by mannan-binding lectin and ficolins revealed new mechanisms of innate immune defence and a diversity of parasite strategies of immune evasion. In the present review, we will discuss the current knowledge of: (1) the molecular mechanism of lectin pathway activation by trypanosomes; (2) the mechanisms of complement evasion by trypanosomes; and (3) host genetic deficiencies of complement lectin pathway factors that contribute to infection susceptibility and disease progression. This review will focus on trypanosomatids, the parasites that cause Chagas disease, leishmaniasis and sleeping sickness (African trypanosomiasis). |
| Databáze: | OpenAIRE |
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