PEG stabilized DNA - poly(ferrocenylsilane) polyplexes for gene delivery
| Autor: | Zoetebier, B., Sohrabi, A., Lou, B., Hempenius, M. A., Hennink, W. E., Vancso, G. J., Sub General Pharmaceutics, Sub Pharmacotherapy, Theoretical, Sub Drug delivery, Dep Farmaceutische wetenschappen, Pharmaceutics, Pharmacoepidemiology and Clinical Pharmacology |
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| Přispěvatelé: | Sub General Pharmaceutics, Sub Pharmacotherapy, Theoretical, Sub Drug delivery, Dep Farmaceutische wetenschappen, Pharmaceutics, Pharmacoepidemiology and Clinical Pharmacology, Developmental BioEngineering, Materials Science and Technology of Polymers, Faculty of Science and Technology |
| Rok vydání: | 2016 |
| Předmět: |
Chemistry(all)
02 engineering and technology Gene delivery 010402 general chemistry Transfection 01 natural sciences Catalysis Coatings and Films chemistry.chemical_compound PEG ratio IR-101401 Materials Testing Side chain Electronic Materials Chemistry Organic chemistry Polyethyleneimine Optical and Magnetic Materials Ferrous Compounds HEPES METIS-317910 Drug Carriers Chemistry Metals and Alloys General Chemistry DNA Silanes 021001 nanoscience & nanotechnology Combinatorial chemistry 22/4 OA procedure 0104 chemical sciences Electronic Optical and Magnetic Materials Surfaces Coatings and Films Surfaces Ceramics and Composites 0210 nano-technology Protein adsorption |
| Zdroj: | Chemical Communications, 52(49), 7707. Royal Society of Chemistry Chemical communications, 52(49), 7707-7710. Royal Society of Chemistry |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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