The apo E/apo CIII molar ratio affects removal of cholesterol ester from modified human lipoproteins injected into cebus monkeys
| Autor: | K. C. Hayes, Zouhair F. Stephan, Joyce C. Gibson |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty DTNB Lipoproteins Dithionitrobenzoic Acid Biology General Biochemistry Genetics and Molecular Biology Absorption Phosphatidylcholine-Sterol O-Acyltransferase chemistry.chemical_compound Apolipoproteins E Internal medicine medicine Animals Cebus Humans General Pharmacology Toxicology and Pharmaceutics Apolipoproteins C Incubation Apolipoprotein C-III Cholesterol Cholesterol HDL General Medicine Metabolism Cholesterol LDL In vitro Endocrinology Postprandial chemistry Cholesteryl ester lipids (amino acids peptides and proteins) Female Cholesterol Esters |
| Zdroj: | Life sciences. 38(15) |
| ISSN: | 0024-3205 |
| Popis: | The removal of postprandial (PP) and postabsorptive (PA) human LDL and HDL cholesterol was examined in cebus monkeys (Cebus albifrons) following in vitro labelling of these lipoproteins by 3H-cholesterol in the presence or absence of DTNB. The removal of LDL cholesteryl ester was 3.5 and 2 times greater than that of HDL in male and female monkeys, respectively. Incubation with DTNB reduced cholesteryl ester removal by 45 and 52% for LDL and HDL, respectively. Cholesteryl ester from PA lipoproteins was removed 80% faster than that PP particles only when plasma was incubated without DTNB. Cholesterol removal from these lipoproteins was positively (r = 0.941) and significantly (P less than 0.001) correlated with the molar apo E/apo CIII ratio. The data suggest that density of lipoproteins was less important than their apoprotein composition in dictating their removal from circulation. |
| Databáze: | OpenAIRE |
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