Magnetic Resonance Imaging of Propagating Waves of Spreading Depression in the Anaesthetised Rat
| Autor: | N. Van Bruggen, A. R. Gardner-Medwin, R. G. Ahier, Stephen R. Williams |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Physics medicine.diagnostic_test Cortical Spreading Depression Brain Magnetic resonance imaging Venous blood Anatomy Oxygenation Magnetic Resonance Imaging Potassium Chloride Rats Rats Sprague-Dawley Nuclear magnetic resonance medicine.anatomical_structure Neurology Cerebral cortex Cortex (anatomy) Cortical spreading depression Coronal plane medicine Animals Neurology (clinical) Cardiology and Cardiovascular Medicine Perfusion |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 14:7-11 |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1038/jcbfm.1994.2 |
| Popis: | Gradient echo magnetic resonance (MR) imaging was used to demonstrate propagating waves of cortical spreading depression (SD) in the anaesthetised rat. SD was initiated by remote perfusion with 150 m M KCl applied for 0.5–2 min to the left parietal cortex. Gradient echo MR images were obtained every 12–30 s in either a vertical coronal section or a horizontal section including the superficial cortex in plan view. Within 2 min of application of KCl, we observed a zone of increased signal intensity (3–15%) on the MR image, up to 2 mm across, lasting approximately 1 min and propagating away from the site of initiation. The mean velocity for 27 of such waves seen in seven animals was calculated to be 2.79 mm/min, with means (±SD) in individual animals averaging 2.90 ± 0.46 mm/min (n = 7). Increased signal intensity in gradient echo images has been attributed to an increased level of oxygenation within the venous blood. Our results are consistent with this interpretation although other physiological changes during SD may also contribute to the signal changes. |
| Databáze: | OpenAIRE |
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