Effect of prophylactic treatment with levetiracetam on the incidence of postattenuation seizures in dogs undergoing surgical management of single congenital extrahepatic portosystemic shunts
| Autor: | Mullins, Ronan A., Sanchez Villamil, Carlos, de Rooster, Hilde, Kummeling, Anne, White, Robert N., Thieman Mankin, Kelley M., Tivers, Michael S., Yool, Donald A., Anderson, Davina M., Pratschke, Kathryn M., Gordo, Ines, Brissot, Herve, Singh, Ameet, Olive, Melanie, Billet, Jean Phillipe, Selmic, Laura E., Kirby, Barbara M., dCSCA AVR, LS Algemene chirurgie |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Levetiracetam Vascular Malformations 040301 veterinary sciences Status epilepticus Loading dose 0403 veterinary science 03 medical and health sciences Dogs Postoperative Complications 0302 clinical medicine Seizures medicine Animals Dog Diseases Postoperative Period Vein Retrospective Studies General Veterinary business.industry Incidence Incidence (epidemiology) Retrospective cohort study 04 agricultural and veterinary sciences Portal System medicine.anatomical_structure 030220 oncology & carcinogenesis Anesthesia Administration Intravenous Anticonvulsants Female medicine.symptom Portosystemic shunt Propofol business medicine.drug |
| Zdroj: | Veterinary Surgery, 48(2), 164. Wiley-Blackwell |
| ISSN: | 0161-3499 |
| DOI: | 10.1111/vsu.13141 |
| Popis: | Objectives: To report (1) the incidence of post-attenuation seizures (PAS) in dogs that underwent single congenital extrahepatic portosystemic shunt (cEHPSS) attenuation and (2) to compare incidence of PAS in dogs that either did or did not receive prophylactic treatment with levetiracetam (LEV). Study Design: Multi-institutional retrospective study. Sample Population: Nine-hundred-and-forty dogs. Methods: Medical records were reviewed to identify dogs that underwent surgical attenuation of a single cEHPSS from January 2005 through July 2017 and developed PAS within seven days postoperatively. Dogs were divided into three groups: no LEV (LEV-); LEV at >15mg/kg TID for >24 hours or a 60mg/kg intravenous loading dose preoperatively, followed by >15mg/kg TID postoperatively (LEV1); ); and LEV at less than 15mg/kg TID, for less than 24 hours preoperatively, or continued at less than 15mg/kg TID postoperatively (LEV2). Results: Nine-hundred-and-forty dogs were included. Seventy-five (8.0%) developed PAS. Incidence of PAS was 35/523 (6.7%), 21/188 (11.2%) and 19/228 (8.3%) in groups LEV-, LEV1 and LEV2, respectively. This difference was not statistically significant (p=0.14). No significant differences between groups of dogs that seized with respect to variables investigated were identified. Conclusions: The overall incidence of PAS was low (8%). Prophylactic treatment with LEV according to the protocols investigated in our study was not associated with a reduced incidence of PAS. Clinical Significance: Prophylactic treatment with LEV does not afford protection against development of PAS. Surgically treated dogs should continue to be monitored closely during the first seven days postoperatively for seizures. |
| Databáze: | OpenAIRE |
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