Relevance of fructose intake in adolescence for fatty liver indices in young adulthood
Autor: | Gunter G. C. Kuhnle, Katharina J. Penczynski, Anette E. Buyken, Ute Alexy, Christian Herder, Karen Della Corte, Michael Roden, Ute Nöthlings, Thomas Remer, Ines Perrar |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male 0301 basic medicine Sucrose Young adulthood Adolescent Medicine (miscellaneous) Physiology Fructose Urine Added sugar Excretion Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sugar intake medicine Humans 030212 general & internal medicine Young adult Sugar 030109 nutrition & dietetics Nutrition and Dietetics business.industry Fatty liver Original Contribution Biomarker medicine.disease Diet Records Adolescence Fatty Liver chemistry Female Steatosis business Non-alcoholic fatty liver disease |
Zdroj: | European Journal of Nutrition |
ISSN: | 1436-6207 |
Popis: | Purpose To examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood. Methods Overall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18–36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5–16.5 years; females: 8.5–15.5 years) were analysed using multivariable linear regression analyses. Results On the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (Ptrend = 0.02) and FLI (Ptrend = 0.03). On the urinary excretion level, however, a higher FE (Ptrend = 0.03) and FE + SE (Ptrend = 0.01) in adolescence were prospectively related to higher adult FLI values. No associations were observed between adolescent sugar excretion and adult HSI. Conclusion The present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted. |
Databáze: | OpenAIRE |
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