Effects of sevelamer and calcium-based phosphate binders on mortality in hemodialysis patients
| Autor: | Maureen Dillon, L. Garrett, Scott Chasan-Taber, R. Zabaneh, Wadi N. Suki, Steven K. Burke, D. Fischer, B. N. Ling, Jon A. Reed, J. L. Cangiano, Andrew T. Blair |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty phosphate-binders medicine.medical_treatment chemistry.chemical_element Sevelamer Calcium Acetates Gastroenterology law.invention Calcium Carbonate chemistry.chemical_compound Older patients Randomized controlled trial law Renal Dialysis Internal medicine medicine Polyamines Humans Aged Chelating Agents hemodialysis business.industry Mortality rate Age Factors Phosphorus Calcium Compounds Middle Aged Phosphate mortality Surgery Arterial calcification Treatment Outcome chemistry Cardiovascular Diseases Nephrology Chronic Disease Female Kidney Diseases Hemodialysis business medicine.drug |
| Zdroj: | Kidney International. 72(9):1130-1137 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/sj.ki.5002466 |
| Popis: | Elevated serum phosphorus and calcium are associated with arterial calcification and mortality in dialysis patients. Unlike calcium-based binders, sevelamer attenuates arterial calcification but it is unknown whether sevelamer affects mortality or morbidity. In a multicenter, randomized, open-label, parallel design trial we compared sevelamer and calcium-based binders on all-cause and cause-specific mortality (cardiovascular, infection, and other) in prevalent hemodialysis patients. A total of 2103 patients were initially randomized to treatment and 1068 patients completed the study. All-cause mortality rates and cause-specific mortality rates were not significantly different. There was a significant age interaction on the treatment effect. Only in patients over 65 years of age was there a significant effect of sevelamer in lowering the mortality rate. There was a suggestion that sevelamer was associated with lower overall, but not cardiovascular-linked, mortality in older patients. We suggest that further research is needed to confirm these findings. |
| Databáze: | OpenAIRE |
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