The Avian Telencephalic Subpallium Originates Inhibitory Neurons That Invade Tangentially the Pallium (Dorsal Ventricular Ridge and Cortical Areas)
| Autor: | Inmaculada Cobos, Luis Puelles, Salvador Martinez |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Telencephalon
Calbindins Time Factors Interneuron Cell Survival Population Cell Count Chick Embryo Biology Quail Calbindin GABA S100 Calcium Binding Protein G Cell Movement Interneurons Cortex (anatomy) medicine Animals Brain Tissue Transplantation Cell Lineage education Molecular Biology gamma-Aminobutyric Acid Cerebral Cortex Neurons Transplantation Chimera education.field_of_study Neocortex Cerebrum Immunochemistry fungi Cell Differentiation Epithelial Cells Anatomy Cell Biology subpallium tangential migration Neuroepithelial cell cortex Phenotype medicine.anatomical_structure DVR nervous system GABAergic neuronal specification Neuroscience Developmental Biology |
| Zdroj: | Developmental Biology. 239(1):30-45 |
| ISSN: | 0012-1606 |
| DOI: | 10.1006/dbio.2001.0422 |
| Popis: | Recent data on the development of the mammalian neocortex support that the majority of its inhibitory GABAergic interneurons originate within the subpallium (ganglionic eminences). Support for such tangential migration into the pallium has come from experiments using fluorescent tracers or lineage analysis with retrovirus, and the phenotypes of mutant mice with different abnormalities in the developing subpallium. In the present study, we describe tangential migration of subpallial-derived neurons in the developing chick telencephalon. Using quail–chick grafts, we precisely identified the neuroepithelial origin, time-course, and pathways of migration, as well as the identity and relative distribution of the diverse tangentially migrated neurons. The analysis of selective grafts of the pallidal and striatal primordia allowed us to determine the relative contribution of each primordium to the population of migrating neurons. Moreover, we found that, like in mammals, the vast majority of the GABAergic and calbindin-immunoreactive neurons within the pallium (dorsal ventricular ridge and cortical areas) have an extracortical, subpallial origin. Our results suggest that the telencephalon of birds and mammals share developmental mechanisms for the origin and migration of their cortical interneurons, which probably first evolved at an earlier stage in the radiation of vertebrates than was thought before. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect