Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study
| Autor: | L Sewell, T A Lionetti, Mary R. Lee, Melanie L. Schwandt, D E Spero, Jared W. Bollinger, Mehdi Farokhnia, J P Amodio, Lorenzo Leggio, Lisa A. Farinelli |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Baclofen Alcohol Drinking Alcohol Self Administration Alcohol use disorder Anxiety Placebo Affect (psychology) 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Outcome Assessment Health Care medicine Humans Biological Psychiatry Craving Biobehavioral Sciences Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Alcoholism Mood chemistry nervous system Schizophrenia Anesthesia GABA-B Receptor Agonists Female Original Article medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | Baclofen has been suggested as a potential pharmacotherapy for alcohol use disorder, but the clinical data are conflicting. Here we investigated the biobehavioral effects of baclofen in a sample of anxious alcohol-dependent individuals. This was a randomized, double-blind, placebo-controlled, human laboratory study in non-treatment seeking alcohol-dependent individuals with high trait anxiety (N=34). Participants received baclofen (30 mg per day) or placebo for at least 8 days, then performed an experimental session consisting of alcohol cue-reactivity followed by alcohol administration procedure (alcohol priming, then alcohol self-administration). Total amount of alcohol self-administered was the primary outcome; alcohol craving, subjective/physiological responses and mood/anxiety symptoms were also evaluated. There was no significant medication effect on the total amount of alcohol consumed during the alcohol self-administration (P=0.76). Baclofen blunted the positive association between maximum breath alcohol concentration during priming and the amount of alcohol consumption (significant interaction, P=0.03). Ratings of feeling intoxicated were significantly higher in the baclofen group after consuming the priming drink (P=0.006). During the self-administration session, baclofen significantly increased ratings of feeling high (P=0.01) and intoxicated (P=0.01). A significant reduction in heart rate (P |
| Databáze: | OpenAIRE |
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