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Purpose This investigation examined the effect of 5 different cements on the retention strength of prefabricated endodontic dowels placed into root canals previously obturated with gutta percha and a zinc oxide/eugenol (ZOE) sealer. Materials and Methods Ninety-six single-rooted teeth were decoronated, filed, cleaned, sequentially shaped, and divided into 6 groups of 16 specimens each. Five of the groups were then obturated with gutta percha and a ZOE sealer. One group was not obturated and served as the control group. Dowel space preparation and dowel cementation for all groups were completed 1 week later. Ten-mm deep dowel spaces were prepared using size 6 Gates Glidden drills. Size 5 Paraposts were then cemented with 5 different cements: Panavia 21 for group 1 (unobturated controls) and group 2; Ketac-Cem glass ionomer for group 3; Fleck's zinc phosphate for group 4; Parapost (composite) Cement for group 5; and C&B Metabond 4-META for group 6. After 48 hours, the dowels were removed using a universal testing machine in tensile mode at 1 mm min−1. Results The following results were found (all values in kg): group 1 (controls; Panavia 21) mean = 61.81, 95% CI =±8.65; group 2 (Panavia 21), mean=43.15, 95% CI =±7.81; group 3 (Ketac-Cem), mean =34.45, 95% CI =±4.93; group 4 (zinc phosphate), mean = 25.07, 95% CI =±5.03; group 5 (Parapost Cement), mean = 24.99, 95% CI =±5.35. None of the group 6 (CB pairwise multiple comparison procedures (Tukey test) showed that group 1 (controls) had significantly greater retention than all other groups (p |