Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation
| Autor: | Jonathan P. May, Eno Hysi, Shyh-Dar Li, Lauren A. Wirtzfeld, Elijus Undzys, Michael C. Kolios |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Effective size Materials science Oxygen saturation lcsh:QC221-246 Photoacoustic imaging in biomedicine 01 natural sciences 010309 optics 03 medical and health sciences Mild hyperthermia 0103 physical sciences Spectral slope medicine lcsh:QC350-467 Radiology Nuclear Medicine and imaging Tumor blood vessels Photoacoustic and ultrasound tissue characterization Tumor Oxygenation lcsh:QC1-999 Atomic and Molecular Physics and Optics 3. Good health Cancer treatment Red blood cell 030104 developmental biology medicine.anatomical_structure Cancer treatment monitoring lcsh:Acoustics. Sound Radiofrequency analysis lcsh:Physics lcsh:Optics. Light Research Article Biomedical engineering Blood vessel |
| Zdroj: | Photoacoustics Photoacoustics, Vol 5, Iss C, Pp 25-35 (2017) |
| Popis: | Frequency analysis of the photoacoustic radiofrequency signals and oxygen saturation estimates were used to monitor the in-vivo response of a novel, thermosensitive liposome treatment. The liposome encapsulated doxorubicin (HaT-DOX) releasing it rapidly (Photoacoustic imaging (VevoLAZR, 750/850 nm, 40 MHz) of EMT-6 breast cancer tumors was performed 30 min pre- and post-treatment and up to 7 days post-treatment (at 2/5/24 h timepoints). HaT-DOX-treatment responders exhibited on average a 22% drop in oxygen saturation 2 h post-treatment and a decrease (45% at 750 nm and 73% at 850 nm) in the slope of the normalized PA frequency spectra. The spectral slope parameter correlated with treatment-induced hemorrhaging which increased the optical absorber effective size via interstitial red blood cell leakage. Combining frequency analysis and oxygen saturation estimates differentiated treatment responders from non-responders/control animals by probing the treatment-induced structural changes of blood vessel. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|