Prognostic Effect of Complex Karyotype, Monosomal Karyotype, and Chromosome 17 Abnormalities in B-Cell Acute Lymphoblastic Leukemia
| Autor: | Priya Khoral, Hong Chang, Eshetu G. Atenafu, Aaron D. Schimmer, Kenneth J. Craddock |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Pathology Multivariate analysis Adolescent Karyotype 03 medical and health sciences Young Adult 0302 clinical medicine Monosomy Internal medicine White blood cell Complex Karyotype medicine Humans Child Aged Retrospective Studies Aged 80 and over Chromosome Aberrations Univariate analysis B-Lymphocytes business.industry Myeloid leukemia Hematology B-cell acute lymphoblastic leukemia Middle Aged Prognosis Chromosome 17 (human) Leukemia Myeloid Acute medicine.anatomical_structure 030220 oncology & carcinogenesis Karyotyping Female business 030215 immunology Monosomal karyotype Chromosomes Human Pair 17 |
| Zdroj: | Clinical lymphoma, myelomaleukemia. 17(4) |
| ISSN: | 2152-2669 |
| Popis: | Background The effect of monosomal karyotype (MK), complex karyotype (CK), and chromosome 17 abnormalities (abnl 17) on prognosis in B-cell acute lymphoid leukemia (B-ALL) has not yet been established. Patients and Methods We conducted a retrospective analysis of prognostic factors on 237 adult patients with B-ALL treated at our institution. Results Older age (older than 60 years), higher white blood cell count (> 30), and abnl 17 were associated with shorter overall survival in univariate analysis, but multivariable analysis only identified older age as an independent poor prognostic actor. There was a significant correlation between abnl 17 and older age. Conclusion In contrast to the patients with acute myeloid leukemia, our results show that MK and CK do not play a predictive role in patients with B-ALL, but further study is required to determine whether specific changes on chromosome 17 might have prognostic value when investigated separately. |
| Databáze: | OpenAIRE |
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