Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle
| Autor: | Mohammad Mehdi Ommati, Fahiel Casillas, Alejandra Ávila-Quintero, Miguel Betancourt, Alma López, Socorro Retana-Márquez, Yvonne Ducolomb, Lizbeth Juárez-Rojas, Jimena Zamora |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
media_common.quotation_subject Veterinary medicine Biology Oogenesis Article ovum Andrology chemistry.chemical_compound Corticosterone In vivo SF600-1100 homeostasis medicine Chronic stress reproductive and urinary physiology media_common Estrous cycle General Veterinary urogenital system oogenesis Oocyte medicine.anatomical_structure chemistry QL1-991 cold stress Animal Science and Zoology female cycles Reproduction Zoology Homeostasis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Animals : an Open Access Journal from MDPI Animals, Vol 11, Iss 2478, p 2478 (2021) Animals Volume 11 Issue 9 |
| ISSN: | 2076-2615 |
| Popis: | Simple Summary Recently, a significant relationship between stress and reproductive failure in women was reported; being one of the possible causes of infertility. The World Health Organization recognizes infertility as a global public health issue; therefore, the interest in understanding the main causes of this issue has increased over the last few decades. Thus, many studies have reported that stress can adversely alter the functionality of the hypothalamic-pituitary-gonadal axis; as well as being one of the reasons of subfertility in patients undergoing in vitro fertilization. Therefore, it can be assumed that stress is closely related to poor in vitro fertilization outcomes. In chronically stressed female rats, irregular estrous cyclicity, increased corticosterone levels, decreased oocyte viability, and increased percentage of abnormal oocytes were obtained in all estrous cycle phases, resulting in reduced oocyte maturation during proestrus. Oocyte maturation disturbed by chronic stress is a crucial factor by which chronic stress disrupts female reproduction. Abstract Background: Stress has been considered as one of the causes of decreased reproductive function in women. However, direct evidence of the effect of chronic stress on oocytes depending on estrous cycle phases is limited. Objective: The present study aimed to evaluate the impact of chronic stress on the viability, integrity, and maturation of rat oocytes depending on estrous cycle phases, specifically proestrus, estrus, and diestrus. Methods: For this purpose, adult female rats were stressed daily by cold water immersion (15 °C) for 30 consecutive days. Results: In chronically stressed female rats, irregular estrous cyclicity, increased corticosterone levels, decreased oocyte viability, and an increased percentage of abnormal oocytes were obtained in all the estrous cycle phases, resulting in reduced oocyte maturation during proestrus. Conclusion: Oocyte maturation disturbed by chronic stress is a crucial factor by which chronic stress disrupts female reproduction |
| Databáze: | OpenAIRE |
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