Greater lifetime stress exposure predicts blunted cortisol but heightened DHEA responses to acute stress

Autor: Jovian C.W. Lam, Brian C. Trainor, George M. Slavich, Andrew P. Yonelinas, Grant S. Shields
Rok vydání: 2018
Předmět:
Male
Aging
050103 clinical psychology
Hydrocortisone
Pituitary-Adrenal System
Physiology
Trier social stress test
Psychology
Medicine
Chronic stress
DHEA
Aetiology
Young adult
Applied Psychology
Pediatric
Psychiatry
05 social sciences
Allostasis
health
General Medicine
Healthy Volunteers
Allostatic load
Psychiatry and Mental health
Clinical Psychology
Mental Health
Public Health and Health Services
Female
social and economic factors
allostatic load
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Adult
Hypothalamo-Hypophyseal System
endocrine system
Adolescent
Dehydroepiandrosterone
cortisol
Stress
Basic Behavioral and Social Science
Article
Young Adult
Clinical Research
2.3 Psychological
Behavioral and Social Science
0502 economics and business
Humans
0501 psychology and cognitive sciences
cumulative life stress
Saliva
disease
business.industry
Stressor
Business and Management
Brain Disorders
Psychological
business
Mind and Body
Biomarkers
Stress
Psychological
050203 business & management
Zdroj: Stress and health : journal of the International Society for the Investigation of Stress, vol 35, iss 1
ISSN: 1532-3005
Popis: Although prior research has examined how early adversity and chronic stress exposure relate to hypothalamic-pituitary-adrenal (HPA) axis responses to acute stress, to date, no studies have examined how stressors occurring over the entire lifespan predict such responses. To address this issue, we recruited 61 healthy young adults and measured their exposure to 55 different types of acute life events and chronic difficulties occurring over the lifespan. In addition, we characterized differences in participants' HPA axis responses to acute stress by measuring their salivary cortisol and DHEA responses to the Trier Social Stress Test for Groups. Greater cumulative stress exposure was associated with a blunted cortisol response, but a heightened DHEA response, to the acute stressor. Moreover, it was participants' exposure to these stressors (i.e., lifetime count), not their perceived severity, which predicted their cortisol and DHEA responses to acute stress. Furthermore, differential effects were observed by stress exposure domain. Notably, only adulthood and marital/partner stressors significantly predicted cortisol responses to acute stress, whereas stress was more uniformly associated with DHEA responses to the acute stressor. These results thus reveal how cumulative stress exposure is associated with HPA axis responsivity to acute stress, while highlighting the fact that different stressors may have substantially different associations with these biological outcomes.
Databáze: OpenAIRE
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