Greater lifetime stress exposure predicts blunted cortisol but heightened DHEA responses to acute stress
Autor: | Jovian C.W. Lam, Brian C. Trainor, George M. Slavich, Andrew P. Yonelinas, Grant S. Shields |
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Rok vydání: | 2018 |
Předmět: |
Male
Aging 050103 clinical psychology Hydrocortisone Pituitary-Adrenal System Physiology Trier social stress test Psychology Medicine Chronic stress DHEA Aetiology Young adult Applied Psychology Pediatric Psychiatry 05 social sciences Allostasis health General Medicine Healthy Volunteers Allostatic load Psychiatry and Mental health Clinical Psychology Mental Health Public Health and Health Services Female social and economic factors allostatic load hormones hormone substitutes and hormone antagonists medicine.drug Adult Hypothalamo-Hypophyseal System endocrine system Adolescent Dehydroepiandrosterone cortisol Stress Basic Behavioral and Social Science Article Young Adult Clinical Research 2.3 Psychological Behavioral and Social Science 0502 economics and business Humans 0501 psychology and cognitive sciences cumulative life stress Saliva disease business.industry Stressor Business and Management Brain Disorders Psychological business Mind and Body Biomarkers Stress Psychological 050203 business & management |
Zdroj: | Stress and health : journal of the International Society for the Investigation of Stress, vol 35, iss 1 |
ISSN: | 1532-3005 |
Popis: | Although prior research has examined how early adversity and chronic stress exposure relate to hypothalamic-pituitary-adrenal (HPA) axis responses to acute stress, to date, no studies have examined how stressors occurring over the entire lifespan predict such responses. To address this issue, we recruited 61 healthy young adults and measured their exposure to 55 different types of acute life events and chronic difficulties occurring over the lifespan. In addition, we characterized differences in participants' HPA axis responses to acute stress by measuring their salivary cortisol and DHEA responses to the Trier Social Stress Test for Groups. Greater cumulative stress exposure was associated with a blunted cortisol response, but a heightened DHEA response, to the acute stressor. Moreover, it was participants' exposure to these stressors (i.e., lifetime count), not their perceived severity, which predicted their cortisol and DHEA responses to acute stress. Furthermore, differential effects were observed by stress exposure domain. Notably, only adulthood and marital/partner stressors significantly predicted cortisol responses to acute stress, whereas stress was more uniformly associated with DHEA responses to the acute stressor. These results thus reveal how cumulative stress exposure is associated with HPA axis responsivity to acute stress, while highlighting the fact that different stressors may have substantially different associations with these biological outcomes. |
Databáze: | OpenAIRE |
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