Mitochondrial DNA deletions accurately detect endometriosis in symptomatic females of child-bearing age
| Autor: | Andrew Harbottle, Andrea Maggrah, Brian Reguly, Jennifer Creed |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Mitochondrial DNA Clinical Biochemistry Endometriosis Disease 030204 cardiovascular system & hematology DNA Mitochondrial 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Discovery medicine Humans Prospective Studies Stage (cooking) Sequence Deletion business.industry Biochemistry (medical) Area under the curve Prognosis medicine.disease Real-time polymerase chain reaction ROC Curve Area Under Curve Case-Control Studies 030220 oncology & carcinogenesis Biomarker (medicine) Female business Follow-Up Studies Hormone |
| Zdroj: | Biomarkers in Medicine. 13:291-306 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2018-0419 |
| Popis: | Aim: Accurate noninvasive diagnostic aids for endometriosis are needed. We evaluated mitochondrial DNA deletions as potential biomarkers for endometriosis. Methods: The diagnostic accuracy of deletions was evaluated by quantitative polymerase chain reaction (QPCR) using well-characterized clinical specimens from all subtypes and stages of endometriosis in a case–control format (n = 182). Results: Deletions (1.2 and 3.7 kb) detected in blood differentiated between endometriosis and controls (area under the curve [AUC] 0.71–0.90). Differences in deletion levels were statistically significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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