Outer membrane vesicles derived fromE. colias novel vehicles for transdermal and tumor targeting delivery
| Autor: | Mao-Ze Wang, Ting-Wei Gu, Jie Niu, Yang Chu, Ke-Ran Guo, Li-Hua Peng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Peptide
02 engineering and technology Pharmacology Administration Cutaneous medicine.disease_cause 03 medical and health sciences Drug Delivery Systems Neoplasms Escherichia coli medicine Stratum corneum Humans General Materials Science Skin 030304 developmental biology Transdermal chemistry.chemical_classification 0303 health sciences Melanoma Vesicle 021001 nanoscience & nanotechnology medicine.disease medicine.anatomical_structure chemistry Drug delivery 0210 nano-technology Bacterial outer membrane |
| Zdroj: | Nanoscale. 12:18965-18977 |
| ISSN: | 2040-3372 2040-3364 |
| Popis: | Transdermal drug delivery is favored in clinical therapy because of its ability to overcome the shortcomings of the first pass elimination of the liver caused by traditional oral administration and the irreversibility of the injection. However, skin stratum corneum (SC) forms a big barrier that precludes most of the biomacromolecules. Herein, we propose the engineering of transformed Escherichia coli (E. coli) derived outer membrane vesicles, detoxified by lysozymes (named TEVs) as the carrier for transdermal drug delivery. TEVs were derived from transgenic E. coli and then modified by an integrin alpha(v)beta(3) (αvβ3) targeting peptide and co-loaded with indocyanine green (ICG) (P-TEVs-G). TEVs were shown to have excellence in penetrating through intact SC without any additional enhancement, followed by targeting of melanoma cells. TEVs are promising nanoplatforms for transdermal and tumor targeting drug delivery with high efficacy and biosafety, possessing great potential in the treatment of superficial tumors. |
| Databáze: | OpenAIRE |
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