Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
| Autor: | Jeffrey Hannah, Pengbo Zhou |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities DNA Repair Ultraviolet Rays DNA damage DNA repair Biochemistry Article Histones Ubiquitin Ultraviolet light Animals Humans skin and connective tissue diseases Molecular Biology SKP Cullin F-Box Protein Ligases biology Cell Cycle Ubiquitination nutritional and metabolic diseases DNA Cell Biology G2-M DNA damage checkpoint Ubiquitin ligase Genes cdc enzymes and coenzymes (carbohydrates) Eukaryotic Cells Carcinogens biology.protein RING Finger Domains Cullin DNA Damage Nucleotide excision repair |
| Zdroj: | DNA Repair. 8:536-543 |
| ISSN: | 1568-7864 |
| Popis: | Eukaryotic cells repair ultraviolet light (UV)- and chemical carcinogen-induced DNA strand-distorting damage through the nucleotide excision repair (NER) pathway. Concurrent activation of the DNA damage checkpoints is also required to arrest the cell cycle and allow time for NER action. Recent studies uncovered critical roles for ubiquitin-mediated post-translational modifications in controlling both NER and checkpoint functions. In this review, we will discuss recent progress in delineating the roles of cullin-RING E3 ubiquitin ligases in orchestrating the cellular DNA damage response through ubiquitination of NER factors, histones, and checkpoint effectors. |
| Databáze: | OpenAIRE |
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