A statistical model for red blood cell survival
| Autor: | Carolyn V. Coulter, Julia Korell, Stephen B. Duffull |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Statistics and Probability
Senescence Erythrocytes Models Statistical Time Factors General Immunology and Microbiology Red Cell Cell Survival Applied Mathematics Hazard ratio Statistical model General Medicine Biology Models Biological General Biochemistry Genetics and Molecular Biology Andrology Modeling and Simulation Animals Humans Computer Simulation General Agricultural and Biological Sciences Red blood cell survival Cell survival Neocytolysis Demography |
| Zdroj: | Journal of Theoretical Biology. 268:39-49 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/j.jtbi.2010.10.010 |
| Popis: | A statistical model for the survival time of red blood cells (RBCs) with a continuous distribution of cell lifespans is presented. The underlying distribution of RBC lifespans is derived from a probability density function with a bathtub-shaped hazard curve, and accounts for death of RBCs due to senescence (age-dependent increasing hazard rate) and random destruction (constant hazard), as well as for death due to initial or delayed failures and neocytolysis (equivalent to early red cell mortality). The model yields survival times similar to those of previously published studies of RBC survival and is easily amenable to inclusion of drug effects and haemolytic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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