Review on circular RNAs and new insights into their roles in cancer
| Autor: | Mengjie Guo, Ye Yang, Hongyan Ren, Chunyan Gu, Xiaozhu Tang, Jinjun Qian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Extracellular transport
PDAC pancreatic ductal adenocarcinoma ceRNAs endogenous RNAs Review siRNAs small interfering RNAs Biochemistry tricRNAs tRNA intronic circRNAs ciRS-7 circular RNA sponge for miR-7 0302 clinical medicine PCR polymerase chain reaction Structural Biology Cancer ncRNAs noncoding RNAs 0303 health sciences MER miRNA response elements CLL chronic lymphocytic leukemia ecircRNAs exonic circular RNAs AML acute myloid leukemia lncRNAs long ncRNA MM multiple myeloma LUAD lung adenocarcinoma Computer Science Applications rRNA ribosomal RNA 030220 oncology & carcinogenesis circRNAs circular RNAs CRC colorectal cancer GC gastric cancer RBP RNA-binding protein RT-PCR reverse transcription-PCR Precursor mRNA RNase ribonuclease EMT epithelial-mesenchymal transition Circular RNAs Biotechnology ciRNAs circular intronic RNAs TNM tumor node metastases Biophysics Computational biology Biology 03 medical and health sciences CML chronic myeloid leukemia NSCLC non-small cell lung cancer microRNA snRNA small nuclear RNA Functions Genetics miRNAs microRNAs UTR untranslated regions Epigenetics EIciRNAs exon–intron RNAs 030304 developmental biology ComputingMethodologies_COMPUTERGRAPHICS RNA ISH in situ hybridization Biomarker Biomarker (cell) ccRCC clear cell renal cell carcinoma BSJ back-splice junction RNA ribonucleic acid qPCR quantitative PCR HCC hepatocellular carcinoma Function (biology) Biogenesis TP248.13-248.65 |
| Zdroj: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 910-928 (2021) |
| ISSN: | 2001-0370 |
| Popis: | Graphical abstract Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by precursor mRNA back-splicing. Unlike canonical linear RNAs, circRNAs form covalently closed, continuous stable loops without a 5′end cap and 3′end poly(A) tail, and therefore are resistant to exonuclease digestion. The majority of circRNAs are highly abundant, and conserved across different species with a tissue or developmental-stage-specific expression. circRNAs have been shown to play important roles as microRNA sponges, regulators of gene splicing and transcription, RNA-binding protein sponges and protein/peptide translators. Emerging evidence reveals that circRNAs function in various human diseases, particularly cancers, and may function as better predictive biomarkers and therapeutic targets for cancer treatment. In consideration of their potential clinical relevance, circRNAs have become a new research hotspot in the field of tumor pathology. In the present study, the current understanding of the biogenesis, characteristics, databases, research methods, biological functions subcellular distribution, epigenetic regulation, extracellular transport and degradation of circRNAs was discussed. In particular, the multiple databases and methods involved in circRNA research were first summarized, and the recent advances in determining the potential roles of circRNAs in tumor growth, migration and invasion, which render circRNAs better predictive biomarkers, were described. Furthermore, future perspectives for the clinical application of circRNAs in the management of patients with cancer were proposed, which could provide new insights into circRNAs in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|