Itolizumab in the Management of Psoriasis with Metabolic Syndrome
| Autor: | Shrichand G Parasramani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
obesity Dermatology Section Every Three Months medicine.medical_treatment Clinical Biochemistry Itolizumab lcsh:Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine anti-cd6 Psoriasis Area and Severity Index Diabetes mellitus Internal medicine Psoriasis Medicine business.industry lcsh:R General Medicine medicine.disease Blood pressure biological therapy high density lipoprotein PUVA therapy 030211 gastroenterology & hepatology Metabolic syndrome business medicine.drug |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 11, Iss 7, Pp WD01-WD02 (2017) |
| Popis: | Psoriasis is a chronic, relapsing, inflammatory disease that has been associated with Metabolic Syndrome (MS), a cluster of cardiovascular risk factors mainly hypertension, obesity, diabetes mellitus and hyperlipidemia. A 49-year-old male patient presented with extensive plaque psoriasis from past 13 years. Past medications included methotrexate, PUVA therapy, topical immunosuppressants and corticosteroids. His baseline Psoriasis Area and Severity Index (PASI) score was 39.8. The patient was screened and diagnosed with MS as per Alberti's Criteria (his waist circumference was 100 cm, blood pressure was 160/100 mmHg and High Density Lipoprotein (HDL) was 30 mg/dl). Considering severity of the disease, in this case we used anti-CD6 humanized monoclonal antibody Itolizumab (1.6 mg/kg body weight) to treat psoriasis and concurrent MS. The patient achieved PASI 50 response in six months after treatment of 10 infusions of Itolizumab (First seven doses were given every fortnightly and the last three doses every month). Further, Itolizumab treatment was continued once every three months and PASI 75 response was achieved at the end of 15 months. His PASI score increased to 30.7 after 18 months. Contemplating link between psoriasis and MS due to possibility of overlapping inflammatory pathways, we instructed patient to reduce his weight and prescribed oral tablet metformin 500 mg twice a day. After losing 6 kg weight, his PASI score came down to 22.2 at the end of 21st month. This suggests that MS was a driving factor in worsening of his psoriasis. Psoriatic patients should be checked simultaneously for co-morbid disease conditions. The report indicates direct association of psoriasis and MS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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