The association between familial and environmental factors and prevalence of congenital hypothyroidism in center of Iran
| Autor: | Mohammad Mehdi Amin, Roya Kelishadi, Masoumeh Rashidi, Mahin Hashemipour, Neda Mehrnejat, Silva Hovsepian, Parinaz Poursafa |
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| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis Prevalence Air pollution Thyrotropin Soil lead Iran 010501 environmental sciences medicine.disease_cause 01 natural sciences Air pollutants Air Pollution Environmental health Congenital Hypothyroidism Humans Environmental Chemistry Medicine Air quality index Retrospective Studies 0105 earth and related environmental sciences business.industry Infant Newborn Retrospective cohort study General Medicine medicine.disease Pollution Congenital hypothyroidism Thyroid function business |
| Zdroj: | Environmental Science and Pollution Research. 28:8434-8441 |
| ISSN: | 1614-7499 0944-1344 |
| DOI: | 10.1007/s11356-020-10959-x |
| Popis: | The aim of this current study is to investigate the association between familial and environmental factors and prevalence of congenital hypothyroidism (CH) in Isfahan province. In this retrospective cohort study, data of the neonates referred for CH screening in different cities of Isfahan province were evaluated. Data regarding air and soil (lead, cadmium) pollutants were collected. The spatial association between mentioned environmental pollutants and prevalence of CH in different cities of Isfahan province was evaluated by using GIS software, and multilevel linear regression was used for evaluating the levels of environmental pollutants and neonates' serum TSH. During the study period, 389,945 neonates were screened, from which 934 diagnosed with CH (1 in 417 neonates).The prevalence rate of CH was ranged from 20 in 10,000 live births to 45 in 10,000 live births in different cities of Isfahan province. There was no any significant association between level of soil lead and cadmium and air pollutants with prevalence of CH in different cities of Isfahan province (P 0.05).There was a significant positive association between soil cadmium and air pollution evaluated by air quality index (AQI) and level of screening serum TSH in CH patients. Considering the significant association between cadmium and AQI with first serum TSH, it is inferred that the interaction of genetic, autoimmune, familial, and environmental factors with each other could influence on neonatal thyroid function. It seems that the role of some mentioned component is more prominent which should be investigated in future researches. |
| Databáze: | OpenAIRE |
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