Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan
| Autor: | Yingying Lu, Mingyang Liu, Yuanzhi He, Lingyue Huang, Yi Li, Mengxue Lv, Hao Du, Jianxin Li, Wenyue Deng |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Kaplan-Meier Estimate Original Studies symptomatic infection 0302 clinical medicine Risk Factors Interquartile range Odds Ratio 030212 general & internal medicine Child biology Viral Epidemiology Virus Shedding C-Reactive Protein Infectious Diseases Child Preschool ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Regression Analysis Female medicine.symptom Coronavirus Infections Microbiology (medical) viral shedding China medicine.medical_specialty Adolescent Fever Pneumonia Viral Asymptomatic coronavirus disease 2019 Betacoronavirus 03 medical and health sciences children 030225 pediatrics Internal medicine medicine pneumonia Humans Lymphocyte Count Pediatrics Perinatology and Child Health Viral shedding Pandemics Retrospective Studies SARS-CoV-2 business.industry C-reactive protein COVID-19 Infant Retrospective cohort study Odds ratio medicine.disease Pneumonia Multivariate Analysis Pediatrics Perinatology and Child Health biology.protein business |
| Zdroj: | Pediatric Infectious Disease Journal The Pediatric Infectious Disease Journal |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/inf.0000000000002729 |
| Popis: | Supplemental Digital Content is available in the text. Background: Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited. This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19. Methods: The clinical and laboratory information of 110 children with COVID-19 at Wuhan Children’s Hospital, Wuhan, China, from January 30 to March 10, 2020, were analyzed retrospectively. Results: The median age was 6 years old. The median period of viral shedding of COVID-19 was 15 days (interquartile range [IQR], 11–20 days) as measured from illness onset to discharge. This period was shorter in asymptomatic patients (26.4%) compared with symptomatic patients (73.6%) (11 days vs. 17 days). Multivariable regression analysis showed increased odds of symptomatic infection was associated with age 3.0 mg/L (OR 4.89; 95% CI: 1.10–21.75; P = 0.037) and presenting pneumonia in chest radiologic findings (OR 8.45; 95% CI: 2.69–26.61; P < 0.001). Kaplan-Meier analysis displayed symptomatic infection (P < 0.001), fever (P = 0.006), pneumonia (P = 0.003) and lymphocyte counts |
| Databáze: | OpenAIRE |
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