Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder
| Autor: | Chw Horne, David P. Lane, K. Mellon, Al Harris, Chris Wright, David E. Neal, P. Johnston |
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| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Receptor ErbB-2 Gene Expression Biology Prostate cancer Epidermal growth factor Proto-Oncogene Proteins medicine Biomarkers Tumor Humans Epidermal growth factor receptor Lung cancer Aged Neoplasm Staging Carcinoma Transitional Cell Urinary bladder Staining and Labeling medicine.disease ErbB Receptors Transitional cell carcinoma medicine.anatomical_structure Oncology Urinary Bladder Neoplasms Cancer cell Mutation Cancer research biology.protein Female Tumor Suppressor Protein p53 Liver cancer Research Article |
| Zdroj: | British Journal of Cancer Scopus-Elsevier |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Expression of the p53, the epidermal growth factor receptor (EGFr; c-erbB-1) and c-erbB-2 proteins was studied in 82 patients with primary transitional cell carcinoma of the bladder using an immuno-histochemical method. Strong or moderate staining was found in 18% of tumours for p53 with weaker staining in a further 36% giving a total of 54% of tumours stained for p53. Strong staining was found in 15% of tumours for c-erbB-2 and in 31% for the EGFr. Tumours invading the bladder muscle were significantly more likely to be strongly stained positively for p53 and/or EGFr compared with superficial tumours: only 15% of invasive tumours were stained negatively for both p53 and EGFr. No statistical association was found between p53 and EGFr expression. Weakly positive associations were found between the expression of c-erbB-2 and p53 and between muscle invasive tumours and increased expression of c-erbB-2. Alterations in the expression of p53, c-erbB-1 and c-erbB-2 were found frequently in human transitional cell carcinoma of the urinary bladder and may be of clinical use in defining patient sub-groups of differing prognosis. |
| Databáze: | OpenAIRE |
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