Prevalence of breast cancer in thyroid diseases: results of a cross-sectional study of 3,921 patients
| Autor: | Salvatore Sorrenti, Marta Bianchini, Enrico De Antoni, Massimino D'Armiento, Natalie Prinzi, Renzo Mocini, Corrado De Vito, Enke Baldini, Antonio Catania, Angela Nesca, Carmela Coccaro, S Carbotta, Salvatore Ulisse, Chiara Tuccilli |
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| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
Pathology Cross-sectional study Autoimmunity anti-tsh receptor antibody anti-thyroglobulin antibody oestrogen receptor breast cancer anti-thyroperoxidase antibody oestrogen thyroid cancer thyroid disease thyroid diseases tsh thyroid hormone receptor thyroid hormone Prevalence Registries Young adult Child Aged 80 and over education.field_of_study Thyroid disease Thyroid Middle Aged medicine.anatomical_structure Italy Oncology Child Preschool Population Surveillance Female Adult medicine.medical_specialty Adolescent Population Breast Neoplasms Young Adult Breast cancer Internal medicine medicine Humans education Aged Autoantibodies business.industry Infant Newborn Infant Cancer Odds ratio medicine.disease Thyroid Diseases Cross-Sectional Studies business |
| Zdroj: | Breast Cancer Research and Treatment. 144:683-688 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-014-2893-y |
| Popis: | Results from national cancer registries reveal an association of thyroid cancers with extra-thyroidal malignancies. In this study, we evaluated the prevalence of breast cancer (BC) in women affected by both benign and malignant thyroid diseases (TD) in comparison to the general population. To this end, 3,921 female patients from central and southern regions of Italy were evaluated. Age-matched analysis of the prevalence of BC was carried out after dividing the patients into three diagnostic categories: (1) 1,149 patients with non-nodular TD; (2) 2350 patients with nodular TD; (3) 422 patients affected by differentiated thyroid cancers. Furthermore, the patients were grouped according to the absence (2,344 patients) or presence (1,453 patients) of anti-thyroglobulin (TgAb) and/or anti-thyroperoxidase (TPOAb) or anti-TSH receptor auto-antibodies (124 patients). BC prevalence in TD patients as a whole was significantly higher compared to the general population, with an odds ratio (OR) of 3.33. Age-matched analysis showed that the risk of a BC in TD patients was higher in younger patients (age 0-44 years), with an OR of 15.24, which decreased with increasing age. Patients without thyroid auto-antibodies showed a higher OR for BC (p = 0.0005) than TD patients with TgAb and/or TPOAb. The results demonstrate that women affected by either benign or malignant thyroid disease have a significantly greater risk of BC, which is higher at a younger age. Furthermore, thyroid auto-antibodies appear to be protective against BC. These findings may contribute to the identification of common genetic and environmental factors underlying this disease association. |
| Databáze: | OpenAIRE |
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