Morbidity in 565 Type 2 Diabetic Patients According to Stage of Nephropathy
| Autor: | Thomas Schleiffer, Horst Brass, Harald Hölken |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Myocardial Infarction Blood Pressure Gastroenterology Nephropathy Cohort Studies Diabetic nephropathy Endocrinology Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria Humans Carotid Stenosis Diabetic Nephropathies Renal replacement therapy Aged Diabetic Retinopathy Proteinuria business.industry Middle Aged medicine.disease Surgery Renal Replacement Therapy Cerebrovascular Disorders Diabetes Mellitus Type 2 Hypertension Female Hypertrophy Left Ventricular Microalbuminuria Morbidity medicine.symptom business Kidney disease |
| Zdroj: | Journal of Diabetes and its Complications. 12:103-109 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/s1056-8727(97)00003-2 |
| Popis: | Between 1988 and 1992, 565 type 2 diabetic patients were examined for nephropathy and diabetes-associated diseases during hospital treatment. Stages of nephropathy were defined as no clinical sign of nephropathy (N = 280), microalbuminuria (N = 38), overt proteinuria (N = 105), impaired renal function (N = 55), and chronic dialysis therapy (N = 87). In dialyzed patients, HbA1c averaged 6.8%, and, in the other groups, HbA1c was between 7.6% and 8.3% (normal range, 3.8%-6.1%). Cataract was not associated with the severity of nephropathy. Stroke was most common in the stage of renal insufficiency (34%). The following complications, as found in medical history or as current event, showed a significant association with the stage of nephropathy and occurred most frequently in dialysis patients (percentage is displayed for patients with nephropathy in comparison to diabetic dialysis patients): hypertension (53%-89%), left ventricular hypertrophy (39%-81%), myocardial infarction (14%-36%), peripheral vascular disease (27%-77%), foot lesions (7%-75%), minor or major amputations (3%-23%), proliferative retinopathy (6%-46%), blindness (2.9%-16.1%), and internal carotid artery stenosis (15%-36%). In this preselected cohort of diabetic patients, a high morbidity was found already without nephropathy that increased several-fold in the course of the development of nephropathy. Our data identify patients with diabetic nephropathy as a high-risk group for excess morbidity. |
| Databáze: | OpenAIRE |
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