Two doses of pandemic influenza A(H1N1) vaccine: tolerability in healthy young children in the Netherlands
| Autor: | Hester E. de Melker, Nicoline A.T. van der Maas, Patricia E. Vermeer-de Bondt, Tessa M. van ’t Klooster, Jeanet M. Kemmeren |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Immunology Immunization Secondary Influenza A Virus H1N1 Subtype Surveys and Questionnaires Injection site Influenza Human Medicine Humans General Pharmacology Toxicology and Pharmaceutics Adverse effect Netherlands business.industry Vaccination Pandemic influenza Infant Influenza pandemic Tolerability Influenza Vaccines Child Preschool Mass vaccination Female business |
| Zdroj: | Human vaccines. 7(10) |
| ISSN: | 1554-8619 |
| Popis: | During the 2009 influenza pandemic, children aged 6 months up to and including 4 years, without chronic illness, were vaccinated with two doses of Pandemrix(®) through mass vaccination in the Netherlands. During the vaccination campaign a warning was issued about fever after the second dose of Pandemrix(®). Therefore, we investigated the tolerability of both doses Pandemrix(®) in these children. Among parents of children eligible for vaccination, 1500 questionnaires were distributed during both, the first and second mass vaccination session. We asked for the occurrence, time interval, and duration of local reactions and systemic adverse events (AEs). The responses were 36.7% and 29.5% after each dose, respectively. Local reactions were reported in 40.4% and 39.3%, most frequently, pain at the injection site. After the first and second dose, 29.6% and 30.7% of all children experienced fever (mean temperature 38.8{degree sign}C). Other systemic AEs were reported in 41.6% and 42.9% of the children. No differences were seen between the first and second dose for all reported AEs except for pallor. One child was hospitalized after the first dose, but a causal relation to the vaccination was considered improbable. In conclusion, fever was frequently reported in children 6 months up to and including 4 years of age after the first and second dose of Pandemrix(®). However, for almost all AEs, including fever, no dose effect was observed. Reported AEs were mostly mild and all were transient. |
| Databáze: | OpenAIRE |
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