HPV-prevalence in elderly women in Denmark
| Autor: | Reza Rafiolsadat Serizawa, Berit Andersen, Hanne Nørgaard Heje, Lise Grupe Larsen, Petra Hall Viborg, Marianne Waldstrøm, Tonje Johansen, Kirsten Marie Jochumsen, Dorthe Ejersbo, Birgitte Schütt Christensen, Jette Christensen, Elsebeth Lynge |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Human papillomavirus medicine.medical_specialty Denmark Prevalence Uterine Cervical Neoplasms Danish 03 medical and health sciences Age 0302 clinical medicine Epidemiology medicine Humans Registries Cervix Early Detection of Cancer Aged Aged 80 and over Cervical cancer Human papillomavirus 16 Human papillomavirus 18 business.industry Papillomavirus Infections Age Factors virus diseases Obstetrics and Gynecology Emigration and Immigration medicine.disease female genital diseases and pregnancy complications Confidence interval language.human_language Postmenopause Menopause 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Screening language Female business Demography |
| Zdroj: | Andersen, B, Christensen, B S, Christensen, J, Ejersbo, D, Heje, H N, Jochumsen, K M, Johansen, T, Larsen, L G, Lynge, E, Serizawa, R, Viborg, P H & Waldstrøm, M 2019, ' HPV-prevalence in elderly women in Denmark ', Gynecologic Oncology, vol. 154, no. 1, pp. 118-123 . https://doi.org/10.1016/j.ygyno.2019.04.680 |
| ISSN: | 0090-8258 |
| Popis: | AIM: In countries like Denmark, cervical cancer incidence is at present relatively high in elderly women, while routine screening stops at age 65 years. On this background, all women aged 69 and above were invited to human papillomavirus (HPV)-screening in Denmark in 2017.METHODS: Women were identified from the Central Population Register and personally invited by digital or ordinary mail to have a screening sample taken by their general practitioner. In four regions, samples were tested for high risk (HPV) with the cobas 4800® HPV-assay, and in the last region with the BD Onclarity® HPV-assay. Participation rate, prevalence of high risk HPV, and proportion of positive samples with HPV16, HPV18, and other high risk HPV-types were tabulated by 5-year age-groups.RESULTS: 455,612 women were invited, and 30.2% (95 confidence interval (CI) 30.0-30.3) participated. Average age of participants was 74.6 years. Overall, 4.3% (95% CI 4.1-4.4) of participants were HPV-positive, of whom 24% had HPV 16/18. HPV-prevalence decreased slightly from 4.5% in women aged 69-73 years to 3.1% in women aged 84-88 years, but was 5.2% in the very small group of participants aged 89+ years.CONCLUSION: Invitation to HPV-screening was well received by elderly women. The HPV-prevalence decreased slightly with increasing age. No rebound of HPV-prevalence after menopause was found when our data were combined with previously published Danish data from younger women. The presently relatively high cervical cancer incidence in elderly women was not reflected in the HPV-prevalence. |
| Databáze: | OpenAIRE |
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