Graft-infiltrating Dendritic Cells and Coronary Endothelial Dysfunction After Human Heart Transplantation

Autor: Paraskevi Petrakopoulou, Sieglinde Kofler, Ingo Kaczmarek, Michael Weis, Cornelia Grimm, Bruno Meiser
Rok vydání: 2008
Předmět:
Adult
Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Time Factors
Intimal hyperplasia
Heart Diseases
Endothelium
T-Lymphocytes
medicine.medical_treatment
Receptors
Cell Surface
Coronary Angiography
Humans
Transplantation
Homologous
Medicine
Lectins
C-Type
Postoperative Period
Prospective Studies
Endothelial dysfunction
Antigen-presenting cell
Ultrasonography
Interventional
Aged
Heart transplantation
Transplantation
Hyperplasia
business.industry
Microcirculation
Myocardium
Dendritic Cells
Dendritic cell
Middle Aged
medicine.disease
Coronary Vessels
Immunohistochemistry
Transplant rejection
medicine.anatomical_structure
Heart Transplantation
Surgery
Endothelium
Vascular
Tunica Intima
Cardiology and Cardiovascular Medicine
business
Cell Adhesion Molecules
Pericardium
Biomarkers
Follow-Up Studies
Zdroj: The Journal of Heart and Lung Transplantation. 27:387-393
ISSN: 1053-2498
Popis: Background Indirect allorecognition is involved in chronic transplant rejection. We prospectively characterized graft-infiltrating dendritic cells (DCs) in sequential myocardial biopsies ( n = 64; 1 to 24 months after transplantation) from 16 patients after heart transplantation (HTx) and analyzed the relation between graft immune activation and structural and functional coronary changes during follow-up. Methods DC invasion (immunostaining) in the human myocardium was detectable early after HTx, increased further during the first year, and decreased constantly thereafter. Also, graft-infiltrating DCs expressed markers of immaturity and maturity and were time-dependently clustered with CD3-positive T cells. Results Both epicardial and microvascular endothelial dysfunction were associated with elevated CD209-positive DCs at 12 months. CD209 positivity early after HTx was an independent marker for coronary endothelial dysfunction during follow-up. Intimal hyperplasia or angiographic disease during follow-up was not associated with myocardial DC infiltration. Conclusions DCs frequently infiltrate the cardiac allograft with a peak during the first post-operative year and time-dependently cluster with T cells. Migratory active graft-infiltrating DCs may serve as a predictor for allograft coronary endothelial dysfunction.
Databáze: OpenAIRE
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