The Gene and the Pseudogene for Mouse p53 Cellular Tumor Antigen Are Located on Different Chromosomes
| Autor: | David Givol, Henryk Czosnek, D D Pravtcheva, Frank H. Ruddle, Moshe Oren, R Zakut-Houri, B Bienz |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Pseudogene
Trisomy Biology Hybrid Cells Chromosome 15 Mice Cricetulus Cricetinae medicine Animals Cloning Molecular Gene Molecular Biology Genetics Chromosome Chromosome Mapping TAF9 DNA Cell Biology medicine.disease Phosphoproteins Molecular biology Neoplasm Proteins Genes Tumor Suppressor Protein p53 Chromosome 21 Chromosome 22 Research Article |
| Zdroj: | Molecular and Cellular Biology. 4:1638-1640 |
| ISSN: | 1098-5549 |
| DOI: | 10.1128/mcb.4.8.1638-1640.1984 |
| Popis: | The chromosomal assignments of the two genes encoding the murine p53 cellular tumor antigen were determined by using a panel of mouse-Chinese hamster somatic cell hybrid clones and a mouse p53-specific cDNA clone. One gene, probably the functional member of the family, was found to be on chromosome 11. The other gene, which is probably a processed pseudogene, was assigned to chromosome 14. The potential relevance of these findings to documented cases of chromosome 11 trisomy are also discussed. |
| Databáze: | OpenAIRE |
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