Accuracy of SD Malaria Ag P.f/Pan® as a rapid diagnostic test in French Amazonia
| Autor: | Hatem Kallel, Félix Djossou, M. Demar, D. Blanchet, Patrick Portecop, Sarah Lemmonier, Jean Marc Pujo, Stéphanie Houcke, Alexis Frémery |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
RC955-962 Plasmodium falciparum PfHRP2 gene deletion Plasmodium vivax Context (language use) Infectious and parasitic diseases RC109-216 Rapid diagnosis tests Arctic medicine. Tropical medicine Internal medicine Positive predicative value parasitic diseases Malaria Vivax Medicine Malaria Falciparum Accuracy Retrospective Studies Rapid diagnostic test biology Diagnostic Tests Routine business.industry Research Reproducibility of Results biology.organism_classification medicine.disease French Guiana Malaria Diagnosis of malaria Infectious Diseases Tropical medicine Parasitology business |
| Zdroj: | Malaria Journal Malaria Journal, Vol 20, Iss 1, Pp 1-7 (2021) |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/s12936-021-03902-z |
| Popis: | Background French Guiana (FG) is a French overseas territory where malaria is endemic. The current incidence rate is 0.74‰ inhabitants, and Plasmodium vivax is widely predominating even though Plasmodium falciparum is still present due to imported cases mainly from Africa. In FG, rapid diagnostic test (SD Malaria Ag P.f/Pan®) is based on the detection of pan-pLDH, PfHRP2, and PfHRP3 antigens, while in South America, the share of deletion of PfHRP2 gene is significantly increasing. Accordingly, the study questions the reliability of RDTs in the Amazonian context. Methods The study is retrospective. It is conducted over 4 years and analysed 12,880 rapid diagnostic tests (RDTs) compared to concomitant Blood Film Tests (BFTs) sampled for malaria diagnosis. Results The global assessment of the accuracy of SD Malaria Ag P.f/Pan® in the diagnostic of malaria shows both Positive and Negative Predictive Values (PPV and NPV) higher than 95%, except for PPV in the diagnosis of malaria to P. falciparum (88%). Overall, the concordance rate between RDT and BFT (positive/positive; negative/negative) was 99.5%. The PPV of the RDT in the follow-up of patients diagnosed with P. falciparum was the lowest during the first 28 days. The PPV of the RDT in the follow-up of patients diagnosed with P. vivax was the lowest during the first 21 days. The global sensitivity of SD Malaria Ag P.f/Pan® test was, on average, 96% (88.2–100) for P. falciparum and 93% (90.6–94.2) for P. vivax. The global specificity was 99.8% (99.5–100) for all included species. Conclusion SD Malaria Ag P.f/Pan® is a reliable rapid test used for the first-line diagnosis in remote healthcare centres. The test results should be interpreted in the light of patient’s recent medical history and the date of arrival to FG. |
| Databáze: | OpenAIRE |
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