A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene–metal-ion contact
| Autor: | Ryosuke Kawagoe, Anna Kanegae, Yusuke Takata, Akio Ojida, Manabu Sugimoto, Kazuteru Usui, Ippei Takashima, Akira Yamashita, Shohei Uchinomiya, Jirarut Wongkongkatep |
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| Rok vydání: | 2021 |
| Předmět: |
Fluorophore
Materials science Metal ions in aqueous solution 010402 general chemistry Ring (chemistry) Photochemistry 01 natural sciences Biochemistry Metal chemistry.chemical_compound symbols.namesake Materials Chemistry Environmental Chemistry QD1-999 Xanthene 010405 organic chemistry General Chemistry Fluorescence 0104 chemical sciences Chemistry chemistry visual_art symbols visual_art.visual_art_medium Titration van der Waals force |
| Zdroj: | Communications Chemistry, Vol 4, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2399-3669 |
| DOI: | 10.1038/s42004-021-00541-y |
| Popis: | Despite continuous and active development of fluorescent metal-ion probes, their molecular design for ratiometric detection is restricted by the limited choice of available sensing mechanisms. Here we present a multicolor and ratiometric fluorescent sensing platform for metal ions based on the interaction between the metal ion and the aromatic ring of a fluorophore (arene–metal-ion, AM, coordination). Our molecular design provided the probes possessing a 1,9-bis(2′-pyridyl)-2,5,8-triazanonane as a flexible metal ion binding unit attached to a tricyclic fluorophore. This architecture allows to sense various metal ions, such as Zn(II), Cu(II), Cd(II), Ag(I), and Hg(II) with emission red-shifts. We showed that this probe design is applicable to a series of tricyclic fluorophores, which allow ratiometric detection of the metal ions from the blue to the near-infrared wavelengths. X-ray crystallography and theoretical calculations indicate that the coordinated metal ion has van der Waals contact with the fluorophore, perturbing the dye’s electronic structure and ring conformation to induce the emission red-shift. A set of the probes was useful for the differential sensing of eight metal ions in a one-pot single titration via principal component analysis. We also demonstrate that a xanthene fluorophore is applicable to the ratiometric imaging of metal ions under live-cell conditions. Fluorescent probes can detect metal ions with high sensitivity, but their design typically relies on a limited number of sensing mechanisms. Here the use of arene–metal-ion contact as a sensing mechanism allows ratiometric detection of metal ions across a broad wavelength range. |
| Databáze: | OpenAIRE |
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