Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process
| Autor: | Ralph N. Martins, Judith Miklossy, Justine A. Fonte, Lorenz Hirt, Rudolf Kraftsik, Amanda McRae |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Aging Pathology medicine.medical_specialty Inflammation Disease Biochemistry Antibodies Pathogenesis Endocrinology Cerebrospinal fluid Alzheimer Disease Genetics medicine Humans Molecular Biology Cells Cultured Aged Aged 80 and over Cerebral Cortex Amyloid beta-Peptides biology Microglia business.industry Cell Biology Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Immunology biology.protein Female Autopsy Antibody Alzheimer's disease medicine.symptom business Biomarkers |
| Zdroj: | Experimental gerontology. 42(4) |
| ISSN: | 0531-5565 |
| Popis: | Immunocompetent microglia play an important role in the pathogenesis of Alzheimer's disease (AD). Antimicroglial antibodies in the cerebrospinal fluid (CSF) in clinically diagnosed AD patients have been previously recorded. Here, we report the results of the analysis of the CSF from 38 autopsy cases: 7 with definite AD; 14 with mild and 10 with moderate Alzheimer's type pathology; and 7 controls. Antimicroglial antibodies were identified in 70% of patients with definite AD, in 80% of patients with moderate and in 28% of patients with mild Alzheimer's type pathology. CSF antimicroglial antibodies were not observed in any of the control cases. The results show that CSF antimicroglial antibodies are present in the majority of patients with definite AD and also in cases with moderate Alzheimer's type changes. They may also indicate dysregulation of microglial function. Together with previous observations, these findings indicate that compromised immune defense mechanisms play an important role in the pathogenesis of AD. |
| Databáze: | OpenAIRE |
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