Nutraceuticals as potential therapeutic agents for colon cancer: a review

Autor: Palaniselvam Kuppusamy, Mashitah M. Yusoff, Solachuddin Jauhari Arief Ichwan, Ilavenil Soundharrajan, Natanamurugaraj Govindan, Gaanty Pragas Maniam
Rok vydání: 2014
Předmět:
COX-2
cyclooxygenase 2
HMG-CoA
3-hydroxy-3-methyl-glutaryl CoA
Drug
IGF
insulin-like growth factor
Colorectal cancer
media_common.quotation_subject
Physical activity
Review
Therapeutics
Disease
Bioinformatics
ACC
acetyl CoA carboxylase
PRAP
prolactin receptor associated protein
Nutraceutical
DHA
decahexaenoic acid
EGCG
epigallocatechingallate
HUVEC
human umbilical vein endothelial cell
DMH
1
2-dimethylhydrazine
TRAIL
tumor necrosis factor-related apoptosis-induced ligand
medicine
General Pharmacology
Toxicology and Pharmaceutics
Marine organisms
GADD
growth arrest and DNA damage
NF-κB
nuclear factor-kappa B
media_common
Plant derivatives
TNF
tumor necrosis factor
LDH
lactate dehydrogenase
business.industry
lcsh:RM1-950
ACF
aberrant crypt foci
DR
death receptor
Cancer
Colorectal carcinogenesis
EPA
eicosapentaenoic acid
medicine.disease
ASTX
astaxanthin
FAS
fatty acid synthase
VEGF
vascular endothelial growth factor
Colon cancer
IL
interleukin
MMP
matrix metallo-proteins
Excessive alcohol use
lcsh:Therapeutics. Pharmacology
ACL
ATP-citrate lyase
5-FU
5-fluorouracil
Nutraceuticals
business
TCA
tricarboxylic acid cycle
Zdroj: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 4, Iss 3, Pp 173-181 (2014)
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2014.04.002
Popis: Colon cancer is a world-wide health problem and the second-most dangerous type of cancer, affecting both men and women. The modern diet and lifestyles, with high meat consumption and excessive alcohol use, along with limited physical activity has led to an increasing mortality rate for colon cancer worldwide. As a result, there is a need to develop novel and environmentally benign drug therapies for colon cancer. Currently, nutraceuticals play an increasingly important role in the treatment of various chronic diseases such as colon cancer, diabetes and Alzheimer׳s disease. Nutraceuticals are derived from various natural sources such as medicinal plants, marine organisms, vegetables and fruits. Nutraceuticals have shown the potential to reduce the risk of colon cancer and slow its progression. These dietary substances target different molecular aspects of colon cancer development. Accordingly, this review briefly discusses the medicinal importance of nutraceuticals and their ability to reduce the risk of colorectal carcinogenesis.
Graphical abstract Nutraceuticals are alternative therapeutic agents to control the colon cancer progression. The nutraceuticals stimulate the normal metabolic function in colon cancer cells and regulate the tumor suppressor genes and immunity. These natural products control the over expression of metabolic enzymes and tumor growth factors in colon cancer cell.
Databáze: OpenAIRE
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