Further Concerns About Glutamine: A Case Report on Hyperammonemic Encephalopathy
| Autor: | Matthias Gautschi, Jukka Takala, Reto Etter, Luca Cioccari, Anja Weck |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Glutamine 610 Medicine & health Critical Care and Intensive Care Medicine Hyperglutaminemia chemistry.chemical_compound Lactulose Internal medicine medicine Humans Hyperammonemia business.industry Catabolism Brain Diseases Metabolic Middle Aged medicine.disease Phenylacetate Endocrinology chemistry Urea cycle Dietary Supplements Sodium benzoate Female business medicine.drug |
| Zdroj: | Cioccari, Luca; Gautschi, Matthias; Etter, Reto; Weck, Anja; Takala, Jukka (2015). Further Concerns About Glutamine: A Case Report on Hyperammonemic Encephalopathy. Critical care medicine, 43(10), e458-e460. Lippincott Williams & Wilkins 10.1097/CCM.0000000000001151 |
| ISSN: | 1530-0293 |
| DOI: | 10.1097/CCM.0000000000001151 |
| Popis: | OBJECTIVE We report a case of a woman with hyperammonemic encephalopathy following glutamine supplementation. DESIGN Case report. INTERVENTIONS Plasma amino acid analysis suggestive of a urea cycle defect and initiation of a treatment with lactulose and the two ammonia scavenger drugs sodium benzoate and phenylacetate. Together with a restricted protein intake ammonia and glutamine plasma levels decreased with subsequent improvement of the neurological status. MEASUREMENTS AND MAIN RESULTS Massive catabolism and exogenous glutamine administration may have contributed to hyperammonemia and hyperglutaminemia in this patient. CONCLUSION This case adds further concerns regarding glutamine administration to critically ill patients and implies the importance of monitoring ammonia and glutamine serum levels in such patients. |
| Databáze: | OpenAIRE |
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