Selective targeting of DC-SIGN by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold
| Autor: | Sheng-Kai Wang, C.J. Lin, Chia-Lung Tsai, Hsin-Chuan Wen, Ting-Feng Chen, Jen-Sheng Huang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Scaffold
Langerin Glycoconjugate 010402 general chemistry 01 natural sciences Catalysis Materials Chemistry Receptor Polyproline helix chemistry.chemical_classification integumentary system biology 010405 organic chemistry Chemistry Metals and Alloys General Chemistry biology.organism_classification 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials DC-SIGN Helix Ceramics and Composites Biophysics biology.protein Tetra |
| Zdroj: | Chemical Communications. 55:9124-9127 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c9cc03124c |
| Popis: | DC-SIGN and langerin receptors both bind to oligomannose but lead to opposite effects upon encountering HIV. Because selective targeting of DC-SIGN can lead to anti-viral effects, we developed a glycoconjugate, which provides over 4800-fold selectivity for DC-SIGN over langerin, by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold. |
| Databáze: | OpenAIRE |
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