Back to the future: Immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain

Autor: Ron Babecoff, Svetlana Bruzil, George H. Lowell, Sagit Ziv, Tamar Ben-Yedidia
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Trivalent influenza vaccine
Influenza vaccine
Cross Protection
T-Lymphocytes
Antibodies
Viral
Epitope
Phosphates
03 medical and health sciences
Immunogenicity
Vaccine
0302 clinical medicine
Immune system
Adjuvants
Immunologic
Immunity
Influenza
Human
Humans
Medicine
Seroconversion
Aluminum Compounds
Immunization Schedule
Aged
Aged
80 and over
Hemagglutination assay
General Veterinary
General Immunology and Microbiology
biology
business.industry
Influenza A Virus
H3N2 Subtype
Public Health
Environmental and Occupational Health
virus diseases
Hemagglutination Inhibition Tests
Antibodies
Neutralizing
Virology
030104 developmental biology
Infectious Diseases
Influenza Vaccines
Vaccines
Subunit
Immunology
biology.protein
Molecular Medicine
Female
Immunization
Antibody
business
030215 immunology
Zdroj: Vaccine. 35:713-715
ISSN: 0264-410X
Popis: We previously reported a 2011/12 study in elderly showing that immunization with the universal influenza vaccine candidate, M-001, three weeks before administering trivalent influenza vaccine (TIV) enhanced seroconversion of Hemagglutination Inhibition (HAI) antibodies against known influenza vaccine strains circulating at that time. We now report that those subjects primed with M-001 prior to TIV in 2011 also showed, in their 2011 sera, significantly more HAI antibodies with improved seroprotection and seroconversion against strain A/Switzerland/9715293/2013(H3N2-like) that caused the 2014/15 influenza epidemic and that wasn't known to circulate in 2011/12. These data indicate that M-001 can provide broadened enhanced immunity extending even to influenza strains destined to circulate in future years. The fact that M-001 stimulates T cell activation and is devoid of HA hypervariable epitopes indicates that such broadened HAI responses effected by M-001 priming is due to extensive T cell priming.
Databáze: OpenAIRE
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