Antimalarial properties of SAABMAL (®): an ethnomedicinal polyherbal formulation for the treatment of uncomplicated malaria infection in the tropics
| Autor: | B Amodu, Martins Emeje, I. C. Obidike |
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| Předmět: |
Drug
quality assessment Plasmodium berghei media_common.quotation_subject Chemistry Pharmaceutical efficacy lcsh:Medicine Antimalarial Pharmacology General Biochemistry Genetics and Molecular Biology Uncomplicated malaria Antimalarials Mice In vivo Chloroquine parasitic diseases Medicine Antimalarial - efficacy - polyherbal - quality assessment Animals Humans Malaria Falciparum media_common Tropical Climate biology business.industry Plant Extracts lcsh:R Experimental Animal Models General Medicine biology.organism_classification medicine.disease Pyrimethamine Original Article polyherbal business Malaria medicine.drug |
| Zdroj: | Europe PubMed Central Scopus-Elsevier The Indian Journal of Medical Research Indian Journal of Medical Research, Vol 141, Iss 2, Pp 221-227 (2015) |
| Popis: | Background & objectives: Malaria is a serious problem in the countries of the developing world. As the malaria parasite has become resistant to most of the antimalaria drugs available currently, there is a need to search for newer drugs. This study reports the pharmaceutical quality and in vivo antimalarial activities of a polyherbal formulation (SAABMAL ® ) used as malarial remedy in Nigeria. Methods: The antiplasmodial activity of SAABMAL ® was determined by using the 4-day suppressive test in Plasmodium berghei-infected mice. The formulation was tried on three different experimental animal models for in vivo antimalarial activities, which are prophylactic, suppressive and curative in mice. Chloroquine and pyrimethamine were used as standard drugs for comparison. Results: The suppressive study showed that, SAABMAL ® (200 and 400 mg/kg/bw) significantly ( p |
| Databáze: | OpenAIRE |
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