Ni-Catalyzed Reductive Liebeskind–Srogl Alkylation of Heterocycles

Autor:	Yuanhong Ma, Jose Cammarata, Josep Cornella
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Communication General Chemistry Alkylation 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Catalysis 0104 chemical sciences Colloid and Surface Chemistry chemistry Isomerization Alkyl
Zdroj:	Journal of the American Chemical Society
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.8b13534
Popis:	Herein we present a Ni-catalyzed alkylation of C–SMe with alkyl bromides for the decoration of heterocyclic frameworks. The protocol, reminiscent to the Liebeskind–Srogl coupling, makes use of simple C(sp2)–SMe to be engaged in a reductive coupling. The reaction is suitable for a preponderance of highly valuable heterocyclic motifs. In addition to cyclic bromides, noncyclic alkyl bromides are well accommodated with exquisite levels of retention over isomerization. The protocol is scalable and permits orthogonal couplings in the presence of other functionalization handles.
Databáze:	OpenAIRE
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